Jump to ContentJump to Main Navigation
Membranes to Molecular MachinesActive Matter and the Remaking of Life$
Users without a subscription are not able to see the full content.

Mathias Grote

Print publication date: 2019

Print ISBN-13: 9780226625157

Published to Chicago Scholarship Online: January 2020

DOI: 10.7208/chicago/9780226625294.001.0001

Show Summary Details
Page of

PRINTED FROM CHICAGO SCHOLARSHIP ONLINE (www.chicago.universitypressscholarship.com). (c) Copyright University of Chicago Press, 2022. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in CHSO for personal use.date: 21 May 2022

Active Matter

Active Matter

Chapter:
(p.56) 2 Active Matter
Source:
Membranes to Molecular Machines
Author(s):

Mathias Grote

Publisher:
University of Chicago Press
DOI:10.7208/chicago/9780226625294.003.0003

This chapter comprises a detailed case history on the emergence of what was to become a model of a molecular “pump,” the photoactive protein bacteriorhodopsin. The surge of research on this brand-new research object is part of the early 1970s’ “membrane moment,” which rapidly transformed the field. The unfolding of research at the University of San Francisco, the Max Planck Institute of Biochemistry, and Cambridge’s Laboratory of Molecular Biology shows a coalescence of concepts and methods from enzymology, organic chemistry, physiology, and structural biology around the concrete materialization of a membrane and its active protein. Thereby, this chapter provides a history of active matter avant la lettre, highlighting the field’s manifold connections to chemistry. Laboratory notebooks reveal transformative steps and the impact of materiality on this research project from an analysis of membrane structures to the study of an exemplary molecular machine. This chapter provides insight into the work style and topics of a novel, influential generation of molecular biologists, which changed the scope of these sciences, and it can be read as an element in a prehistory of optogenetics, a current approach that makes use of such molecular machinery to modify neuronal activity.

Keywords:   cryo-electron microscopy, bioenergetics, Richard Henderson, laboratory notebooks, Dieter Oesterhelt, Max Planck Institute of Biochemistry, Laboratory of Molecular Biology Cambridge, rhodopsin, pump, 1970s

Chicago Scholarship Online requires a subscription or purchase to access the full text of books within the service. Public users can however freely search the site and view the abstracts and keywords for each book and chapter.

Please, subscribe or login to access full text content.

If you think you should have access to this title, please contact your librarian.

To troubleshoot, please check our FAQs, and if you can't find the answer there, please contact us.