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Diving Seals and Meditating YogisStrategic Metabolic Retreats$
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Robert Elsner

Print publication date: 2015

Print ISBN-13: 9780226246710

Published to Chicago Scholarship Online: January 2016

DOI: 10.7208/chicago/9780226247045.001.0001

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PRINTED FROM CHICAGO SCHOLARSHIP ONLINE (www.chicago.universitypressscholarship.com). (c) Copyright University of Chicago Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in CHSO for personal use.date: 25 October 2021

The conditioning phenomenon

The conditioning phenomenon

(p.89) 6 The conditioning phenomenon
Diving Seals and Meditating Yogis

Robert Elsner

University of Chicago Press

This chapter examines the phenomenon of cardiovascular preconditioning. This term has been applied to the unexpectedly improved cellular survivability and reduced metabolism that result from the induction of brief periods of decreased or arrested blood flow. Preconditioning may be induced in most organs, including heart, liver, muscle, brain, and intestine. The initial tissue exposures to lack of circulation are applied sequentially, lasting a few minutes each, during which blood flow is prevented or much reduced, alternating with restoration of normal perfusion. Cellular reactions are so modified by these brief cycles of circulation, resulting in the inexorable alteration of downstream tissues toward lower oxygen, increased carbon dioxide, and increasing acidity, as to render them tolerant of subsequent more prolonged blood flow reduction. The reaction is demonstrable in two phases, with an immediate one lasting a few hours and a subsequent effect delayed for hours to days.

Keywords:   cardiovascular preconditioning, cellular survivability, reduced metabolism, blood flow reduction

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